Â.. ACE inhibitors help preserve kidney function in IgA nephropathy For young individuals with the kidney disease IgA nephropathy , early treatment with angiotensin-converting enzyme inhibitors can reduce the long-term threat of irreversible kidney damage, in the June Journal of the American Culture of Nephrology suggests a study. These results in youthful individuals are of particular interest because they could offer a way of limiting the near future need for renal substitute therapy in sufferers with IgAN, responses Dr.The most common of these adverse events were top respiratory tract infection, headaches, and diarrhea . Twelve patients discontinued the analysis drug due to adverse occasions in weeks 0 to 3, with similar frequencies over the groups . In a few months 3 to 6, a complete of 244 patients had 471 adverse events. The most typical events were upper respiratory tract infection and headache . Six patients discontinued the study drug owing to adverse events in a few months 3 to 6. A complete of 24 sufferers got 32 serious adverse events . Two patients in the 10-mg tofacitinib group had congestive heart failure: a 59-year-old woman had two episodes and recovered, and a 79-year-old female with a brief history of cardiovascular disease and diabetes got diarrhea accompanied by renal failure and congestive heart failure, hyperkalemia, and, finally, asystole that resulted in her death on day 107.