She was had and married an unaffected child. Magnetic resonance imaging of the brain showed still left hippocampal sclerosis with small hippocampal quantity and an increased transmission on T2-weighted scanning. Her twin had two simple febrile seizures, at 6 weeks and 4 years. Neuropsychological testing showed average intelligence. During evaluation, she was functioning as a nurse. The findings on brain MRI were within normal limits. The proband had a heterozygous base change c. We detected this mutation in DNA extracted from the proband’s lymphocytes, locks, buccal cells, epidermis fibroblasts, and cell lines produced from olfactory neuroepithelium and didn’t observe it in DNA extracted from cells obtained from her twin . We did not identify the mutation in DNA purified from lymphocytes from the parents and the old sibling with a history of febrile seizures.Angiogenesis is known to have a significant role in breast tumor also, and although previous research combining chemotherapy with the antiangiogenesis drug bevacizumab delayed disease progression, they possess not extended overall survival. In addition to blocking the HER2-controlled growth pathway directly, anti-HER2 drugs contribute to suppression of tumor-connected blood vessels also. Previous studies in Jain's lab suggested that the proangiogenic factor VEGF might overcome the antiangiogenic effects of anti-HER2 drugs. This observation led the researchers to research whether blocking the VEGF pathway would improve the total results of anti-HER2 treatment.